Extended release parenteral dosages forms have been successfully used for the treatment of a variety of diseases. To assure the performance and safety of these products, the development of a suitable in-vitro release testing method is crucial. A single approach should not be set for in-vitro release testing given the wide range of controlled release parenteral products; they noted a need for general guiding principles and encouraged research to ensure a scientific basis for the development of different tests, procedures and acceptance criteria. In the pharmaceutical industry, dissolution testing is a very important tool in drug development and quality control. Understanding the factors influencing drug release, both from an in-vivo and an in-vitro perspective, is essential for the development of meaningful in-vitro release tests and performance specifications. At present, there is a lack of standard pharmacopeial/regulatory tests for controlled release parenteral products and this poses a major obstacle in their development and regulatory processes. The aim of this review is to provide the reader with a brief description on factors accelerating in-vitro drug release followed by current accelerated in-vitro release testing methods for parenteral dosage forms.
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